Start in Reno, but you probably shouldn’t stay there too long or you’ll spend your entire trip playing slot machines in the airport. Head west on 80 to Truckee. In Truckee stop for breakfast at Wild Cherries, then head south on 89 towards the lake.
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Stop at Squaw Valley to mountain bike or play disc golf, then keep heading south. At Emerald Bay get out of the car to hike to Eagle Falls.
In South Lake, rent a boat so you can get out onto the water for a bit. Make sure to get a cheeseburger at Fatburger.
To work off your burger head to Heavenly for some hiking. Or, you can take the gondola to the top to minimize your effort.
Head back to the lake and drive north. When you hit Lake Tahoe State Park detour to Sand Harbor for some beach time.
When you get back to Tahoe City, raft the Truckee river, Lake Tahoe’s only outsource.